CAR-T Cell Transcriptomics
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Description
CAR-T cell therapy is hailed as one of the greatest cancer therapy breakthroughs of the last decade. But we still don't know a lot about what makes some CARs better at clearing cancer and why some CARs are more durable. Here we did RNA-seq analysis on both CD4 and CD8 CAR T cells with 3 different constructs to analyze their differences.
R, Python
RNA-Seq, Data Mining, DE, Pathway Analysis, Immune Profiling
Project Stage
Middle
Avg. Hours / Week
5
Project Provider
Wes Wilson / Mike Milone
Commitment (Months)
6
Spots Open
2
Project Lead
Wes Wilson
Publication if successful?
Yes
Trainee authorship criteria (if applicable)
NOTE: You can also complete the python versions of these trainings if you want (RNA-Seq should still be done with R). Additionally, preference will be given to those who have knowledge about scRNA-Seq, which you can get from the BIG scRNA-Seq workshop: https://www.bigbioinformatics.org/intro-to-scrnaseq