BRCA1-NRF2 relationship in health and disease

Active:

true

Description

Recent evidence has revealed that BRCA1 supports NRF2 activity under a variety of conditions. Interestingly, it is not known how this relationship impacts cancers that are BRCA1 mutants, or those which are BRCA1-deficient like Ewing Sarcoma. Interestingly, we have found a fundamental BRCA1-NRF2 relationship that drives fundamental cell state changes in Breast Cancer, Ewing Sarcoma, and normal breast development. This project uses HTS to better characterize that relationship.

R

RNA-Seq, ChIP-Seq, Data Mining, Data Integration

Project Stage

Late

Avg. Hours / Week

7

Project Provider

Alex Bishop, D.Phil.

Commitment (Months)

6

Spots Open

1

Project Lead

Nicklas Bassani & Henry Miller

Publication if successful?

Yes

Trainee authorship criteria (if applicable)

Trainees who contribute meaningfully to the project will be listed as co-authors. E.g., performing an entire core analysis or developing a core component of project software.

Required Skill Assessments

ChIP-Seq Analysis

RNA-Seq Analysis

R for Data Science

R Programming