BRCA1-NRF2 relationship in health and disease
Recent evidence has revealed that BRCA1 supports NRF2 activity under a variety of conditions. Interestingly, it is not known how this relationship impacts cancers that are BRCA1 mutants, or those which are BRCA1-deficient like Ewing Sarcoma. Interestingly, we have found a fundamental BRCA1-NRF2 relationship that drives fundamental cell state changes in Breast Cancer, Ewing Sarcoma, and normal breast development. This project uses HTS to better characterize that relationship.
RNA-Seq, ChIP-Seq, Data Mining, Data Integration
Avg. Hours / Week
Alex Bishop, D.Phil.
Nicklas Bassani & Henry Miller
Publication if successful?
Trainee authorship criteria (if applicable)
Trainees who contribute meaningfully to the project will be listed as co-authors. E.g., performing an entire core analysis or developing a core component of project software.