R-loops across the CCLE (Merck Project)
Merck has provided the funding to measure R-loop levels across dozens of cancer cell lines. These cell lines also (mostly) have data in the CCLE, including genome sequencing, RNA sequencing, epigenomics, drug sensitivity, and gene dependency data. Our goal is to figure out, within these datasets, what correlates with R-loop levels. This is a major pillar of the "loop"-ome project and helps us build a systems biology understanding of R-loops in normal physiology and disease.
RNA-Seq, Data Integration, Data Mining
Avg. Hours / Week
Alex Bishop, D.Phil.
Publication if successful?
Trainee authorship criteria (if applicable)
Trainees who contribute meaningfully to the project will be listed as co-authors. E.g., performing an entire core analysis or developing a core component of project software.