R-loops and the Aging Epigenome

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Description

Recent evidence has revealed the central contribution of epigenetic dysregulation in organismal aging. Curiously, R-loops seem to play an important physiological role in preserving normal epigenetic stability. In this project, we will generate DRIP-Sequencing data in epigenetically-aged cells along with several other sequencing datasets.

R, Bash

RNA-Seq, ChIP-Seq, scRNA-Seq, Data Integration, Data Mining, Snakemake, Linux

Project Stage

Early

Avg. Hours / Week

Project Provider

Alex Bishop, D.Phil.

Commitment (Months)

Spots Open

Project Lead

Henry Miller

Publication if successful?

Yes

Trainee authorship criteria (if applicable)

Trainees who contribute meaningfully to the project will be listed as co-authors. E.g., performing an entire core analysis or developing a core component of project software.

Required Skill Assessments