R-loops and the Aging Epigenome
Recent evidence has revealed the central contribution of epigenetic dysregulation in organismal aging. Curiously, R-loops seem to play an important physiological role in preserving normal epigenetic stability. In this project, we will generate DRIP-Sequencing data in epigenetically-aged cells along with several other sequencing datasets.
RNA-Seq, ChIP-Seq, scRNA-Seq, Data Integration, Data Mining, Snakemake, Linux
Avg. Hours / Week
Alex Bishop, D.Phil.
Publication if successful?
Trainee authorship criteria (if applicable)
Trainees who contribute meaningfully to the project will be listed as co-authors. E.g., performing an entire core analysis or developing a core component of project software.