R-loops and the Aging Epigenome

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Description

Recent evidence has revealed the central contribution of epigenetic dysregulation in organismal aging. Curiously, R-loops seem to play an important physiological role in preserving normal epigenetic stability. In this project, we will generate DRIP-Sequencing data in epigenetically-aged cells along with several other sequencing datasets.

R, Bash

RNA-Seq, ChIP-Seq, scRNA-Seq, Data Integration, Data Mining, Snakemake, Linux

Project Stage

Early

Avg. Hours / Week

5

Project Provider

Alex Bishop, D.Phil.

Commitment (Months)

6

Spots Open

2

Project Lead

Henry Miller

Publication if successful?

Yes

Trainee authorship criteria (if applicable)

Trainees who contribute meaningfully to the project will be listed as co-authors. E.g., performing an entire core analysis or developing a core component of project software.

Required Skill Assessments

Linux for Bioinformatics

R Programming

ChIP-Seq Analysis

RNA-Seq Analysis

R for Data Science